diff --git a/Lib/test/test_io.py b/Lib/test/test_io.py
index 99ab6c7ba..b023b1c5d 100644
--- a/Lib/test/test_io.py
+++ b/Lib/test/test_io.py
@@ -5053,13 +5053,11 @@ class SignalsTest(unittest.TestCase):
                 if e.errno != errno.EBADF:
                     raise
 
-    @unittest.skip("TODO: RUSTPYTHON; thread 'main' (103833) panicked at crates/vm/src/stdlib/signal.rs:233:43: RefCell already borrowed")
     @requires_alarm
     @support.requires_resource('walltime')
     def test_interrupted_write_retry_buffered(self):
         self.check_interrupted_write_retry(b"x", mode="wb")
 
-    @unittest.skip("TODO: RUSTPYTHON; thread 'main' (103833) panicked at crates/vm/src/stdlib/signal.rs:233:43: RefCell already borrowed")
     @requires_alarm
     @support.requires_resource('walltime')
     def test_interrupted_write_retry_text(self):
@@ -5069,10 +5067,6 @@ class SignalsTest(unittest.TestCase):
 class CSignalsTest(SignalsTest):
     io = io
 
-    @unittest.skip("TODO: RUSTPYTHON; thread 'main' (103833) panicked at crates/vm/src/stdlib/signal.rs:233:43: RefCell already borrowed")
-    def test_interrupted_read_retry_buffered(self):
-        return super().test_interrupted_read_retry_buffered()
-
 class PySignalsTest(SignalsTest):
     io = pyio
 
diff --git a/crates/vm/src/signal.rs b/crates/vm/src/signal.rs
index 16a097ea6..d1ddd8c3c 100644
--- a/crates/vm/src/signal.rs
+++ b/crates/vm/src/signal.rs
@@ -88,17 +88,23 @@ fn trigger_signals(vm: &VirtualMachine) -> PyResult<()> {
     let signal_handlers = vm
         .signal_handlers
         .get()
-        .expect("should never fail since we check above")
-        .borrow();
+        .expect("should never fail since we check above");
 
     for (signum, trigger) in TRIGGERS.iter().enumerate().skip(1) {
         let triggered = trigger.swap(false, Ordering::Relaxed);
+        if !triggered {
+            continue;
+        }
 
         // SAFETY: TRIGGERS has the same length as the signal_handlers
         let signum = unsafe { SignalNum::new_unchecked(signum as i32) };
 
-        if triggered
-            && let Some(handler) = &signal_handlers[signum]
+        // Read the handler out and drop the borrow before running it. A
+        // handler is free to call signal.signal(), which takes the same cell
+        // mutably, and a live read borrow turns that into a panic.
+        let handler = signal_handlers.borrow()[signum].clone();
+
+        if let Some(handler) = handler
             && let Some(callable) = handler.to_callable()
         {
             callable.invoke((signum.as_i32(), vm.ctx.none()), vm)?;
diff --git a/extra_tests/snippets/stdlib_signal.py b/extra_tests/snippets/stdlib_signal.py
index 9d0b13bbd..50a025a06 100644
--- a/extra_tests/snippets/stdlib_signal.py
+++ b/extra_tests/snippets/stdlib_signal.py
@@ -41,3 +41,39 @@ if "win" not in sys.platform:
     time.sleep(2.0)
 
     assert signals == [signal.SIGALRM, signal.SIGALRM]
+
+    # A handler may call signal.signal(), and the usual reason is to disarm
+    # itself. Reading the handler table while the handler runs used to be a
+    # crash rather than a rearm.
+    rearmed = []
+
+    def rearm(signum, frame):
+        rearmed.append(signum)
+        signal.signal(signal.SIGALRM, signal.SIG_IGN)
+
+    signal.signal(signal.SIGALRM, rearm)
+    signal.raise_signal(signal.SIGALRM)
+    assert rearmed == [signal.SIGALRM], rearmed
+    assert signal.getsignal(signal.SIGALRM) is signal.SIG_IGN
+
+    # The same goes for arming a different signal from inside a handler.
+    armed = []
+
+    def target(signum, frame):
+        armed.append("target")
+
+    def arm_other(signum, frame):
+        armed.append("arm_other")
+        signal.signal(signal.SIGUSR2, target)
+
+    signal.signal(signal.SIGUSR1, arm_other)
+    signal.raise_signal(signal.SIGUSR1)
+    assert armed == ["arm_other"], armed
+    assert signal.getsignal(signal.SIGUSR2) is target
+
+    signal.raise_signal(signal.SIGUSR2)
+    assert armed == ["arm_other", "target"], armed
+
+    signal.signal(signal.SIGALRM, signal.SIG_DFL)
+    signal.signal(signal.SIGUSR1, signal.SIG_DFL)
+    signal.signal(signal.SIGUSR2, signal.SIG_DFL)